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Solid Phase Synthesis of a Functionalized Bis-Peptide Using "Safety Catch" Methodology
Published on: May 15, 2012
Solid-Phase Synthesis of Gly-Ψ[CH(CF3)NH]-Peptides
Clara Sgorbati1, Eliana Lo Presti2, Greta Bergamaschi2
1Department of Chemistry, Materials, and Chemical Engineering "G. Natta", Politecnico di Milano, Via Mancinelli 7, 20131 Milan, Italy.
Abstract:
The solid-phase synthesis of Gly-Ψ[CH(CF3)NH]-peptides is presented. In order to achieve this goal, the synthesis of Gly-Ψ[CH(CF3)NH]-dipeptides having the C-terminus unprotected, the N-terminus protected as Fmoc- or Teoc-, and possibly side chain functionalities protected with acid-labile protecting groups has been developed. A selected small library of six peptidomimetics, encompassing analogues of biological relevant peptides, have been obtained in high purity.
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