Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dual-Responsive Chitosan-Grafted PNIPAAm Hydrogel Eye Drop Incorporating Insulin-Imprinted Microgels for Dry Eye Syndrome Treatment.

Macromolecular bioscience·2026
Same author

Comparing UV-enhanced and direct reduction strategies for CD8⁺ T-cell electrochemical detection.

Scientific reports·2026
Same author

Triple-Cation Perovskite Photoanodes for Solar Water Splitting: From Photovoltaic-Assisted to Immersed Photoelectrochemical Operation.

Micromachines·2026
Same author

Tunable gelatin-based semi-IPN adhesive hydrogel for enhanced self-healing and hemostatic performance.

Biomaterials advances·2026
Same author

Rational Design of NIR-Responsive, Disulfide-Modified Bio-MOF with Antibacterial and Osteogenic Activity.

ACS applied bio materials·2026
Same author

Corrigendum to "Robust and double-layer micro-patterned bioadhesive based on silk nanofibril/GelMA- alginate for stroma tissue engineering" [International Journal of Biological Macromolecules, 183(2021) 1013-1025].

International journal of biological macromolecules·2026

Related Experiment Video

Updated: Nov 3, 2025

Preparation and Characterization of Graphene-Based 3D Biohybrid Hydrogel Bioink for Peripheral Neuroengineering
10:17

Preparation and Characterization of Graphene-Based 3D Biohybrid Hydrogel Bioink for Peripheral Neuroengineering

Published on: May 16, 2022

2.4K

A three-dimensional nerve guide conduit based on graphene foam/polycaprolactone.

Neda Bahremandi Tolou1, Hamidreza Salimijazi2, Mahshid Kharaziha2

  • 1Department of Materials Engineering, Isfahan University of Technology, Isfahan, 84156-83111, Iran; ENEA Casaccia, Italian National Agency for New Technologies, Energy and Sustainable Economic Development, Rome, Italy.

Materials Science & Engineering. C, Materials for Biological Applications
|June 4, 2021
PubMed
Summary

A novel three-dimensional graphene foam/polycaprolactone nanocomposite was developed for peripheral nerve tissue engineering. This conductive scaffold enhances electrical and mechanical properties, promoting nerve cell growth for potential therapeutic applications.

Keywords:
BiomaterialsCVDChemical vapor depositionGraphene foamsNanocompositesNerve guidance conduitPolycaprolactone

More Related Videos

Improved 3D Hydrogel Cultures of Primary Glial Cells for In Vitro Modelling of Neuroinflammation
09:19

Improved 3D Hydrogel Cultures of Primary Glial Cells for In Vitro Modelling of Neuroinflammation

Published on: December 8, 2017

15.1K
Transplantation of Schwann Cells Inside PVDF-TrFE Conduits to Bridge Transected Rat Spinal Cord Stumps to Promote Axon Regeneration Across the Gap
08:05

Transplantation of Schwann Cells Inside PVDF-TrFE Conduits to Bridge Transected Rat Spinal Cord Stumps to Promote Axon Regeneration Across the Gap

Published on: November 3, 2017

7.2K

Related Experiment Videos

Last Updated: Nov 3, 2025

Preparation and Characterization of Graphene-Based 3D Biohybrid Hydrogel Bioink for Peripheral Neuroengineering
10:17

Preparation and Characterization of Graphene-Based 3D Biohybrid Hydrogel Bioink for Peripheral Neuroengineering

Published on: May 16, 2022

2.4K
Improved 3D Hydrogel Cultures of Primary Glial Cells for In Vitro Modelling of Neuroinflammation
09:19

Improved 3D Hydrogel Cultures of Primary Glial Cells for In Vitro Modelling of Neuroinflammation

Published on: December 8, 2017

15.1K
Transplantation of Schwann Cells Inside PVDF-TrFE Conduits to Bridge Transected Rat Spinal Cord Stumps to Promote Axon Regeneration Across the Gap
08:05

Transplantation of Schwann Cells Inside PVDF-TrFE Conduits to Bridge Transected Rat Spinal Cord Stumps to Promote Axon Regeneration Across the Gap

Published on: November 3, 2017

7.2K

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Nanotechnology

Background:

  • Peripheral nerve injuries pose significant challenges in regenerative medicine.
  • Developing advanced biomaterials is crucial for effective nerve regeneration.
  • Existing conduits often lack optimal electrical and mechanical cues for nerve repair.

Purpose of the Study:

  • To develop a novel 3D graphene foam/polycaprolactone (3D-GF/PCL) nanocomposite nerve guide conduit.
  • To evaluate the electrical, mechanical, and biological properties of the developed nanocomposite.
  • To assess its potential for peripheral nerve tissue engineering.

Main Methods:

  • Synthesis of 3D graphene foam (3D-GF) via chemical vapor deposition (CVD).
  • Coating of 3D-GF with polycaprolactone (PCL) to form a composite scaffold.
  • Characterization of electrical conductivity, mechanical properties, and surface morphology.
  • In vitro assessment of PC12 cell proliferation and neurite extension.

Main Results:

  • The 3D-GF/PCL nanocomposite achieved an electrical conductivity of 25 S.m⁻¹.
  • Enhanced mechanical properties were observed compared to pure PCL scaffolds.
  • Increased PC12 cell proliferation and extension were noted on the 3D-GF/PCL nanocomposite.
  • Wettability, surface porosity, and morphology remained largely unchanged.

Conclusions:

  • The developed 3D-GF/PCL nanocomposite exhibits promising electrical and mechanical properties for nerve regeneration.
  • The scaffold supports and enhances peripheral nerve cell growth in vitro.
  • 3D-GF/PCL nanocomposites represent a versatile system for peripheral nerve tissue engineering applications.