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Updated: Feb 10, 2026

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Rational Design of NIR-Responsive, Disulfide-Modified Bio-MOF with Antibacterial and Osteogenic Activity.

Kiana Mohagheghiyan1, Mahshid Kharaziha1, Mahshid Shokri1,2

  • 1Department of Materials Engineering, Isfahan University of Technology, Isfahan 84156-83111, Iran.

ACS Applied Bio Materials
|February 9, 2026
PubMed
Summary

This study introduces a novel near-infrared (NIR)-responsive metal-organic framework (Bio-Zn@S-MOF) for enhanced bone healing. The material exhibits antibacterial, antioxidant, and osteogenic properties, offering a promising strategy for controlling postoperative infections.

Keywords:
3,3′-dithiodipropionic acidadeninebioactive metal−organic frameworkinfectionmelatonin

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Orthopedic Surgery

Background:

  • Postoperative infections pose a significant challenge to surgical healing.
  • Current treatments for bone infections often face limitations in efficacy and side effects.

Purpose of the Study:

  • To design and synthesize a near-infrared (NIR)-responsive, disulfide-functionalized bioactive metal-organic framework (Bio-Zn@S-MOF) for enhanced bone tissue regeneration and infection control.
  • To investigate the stimuli-responsive drug release, antioxidant, cytocompatibility, osteogenic, and bactericidal properties of the developed material.

Main Methods:

  • Synthesis of a bioactive metal-organic framework (Bio-Zn@S-MOF) using zinc cations, adenine, and 3,3'-dithiodipropionic acid (DTPA) ligands.
  • Evaluation of redox-active disulfide bonds for stimuli-responsive melatonin release under acidic and NIR-irradiated conditions.
  • Assessment of antioxidant activity, free radical scavenging, cytocompatibility with MG63 and RAW 264.7 cells, and promotion of osteogenic differentiation.
  • In vitro testing of bactericidal activity, with and without NIR light irradiation.

Main Results:

  • The developed Bio-Zn@S-MOF demonstrated strong antioxidant activity with over 91.0% free radical scavenging within 24 hours.
  • The material exhibited excellent cytocompatibility and promoted osteogenic differentiation while suppressing intracellular reactive oxygen species (ROS).
  • Remarkable in vitro bactericidal activity was observed, significantly enhanced by NIR light irradiation.

Conclusions:

  • The NIR-responsive Bio-Zn@S-MOF integrates light-triggered bactericidal and antioxidant activities with osteogenic potential.
  • This novel material presents a promising therapeutic strategy for infection control and bone tissue regeneration in surgical settings.