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Updated: Nov 3, 2025

Author Spotlight: Advancements in Molecular Biomarker Testing for Non-Squamous Non-Small Cell Lung Cancer
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Published on: September 8, 2023

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Current clinical trials and patent update on lung cancer: a retrospective review

Harshul Batra1, Shrikant Pawar2, Dherya Bahl3

  • 1Neuroscience Institute & Center for Behavioral Neuroscience, Georgia State University, 789 Petit Science Center, Atlanta, GA 30303, USA.

Lung Cancer Management
|June 4, 2021
PubMed

Insights

This study analyzed 6092 lung cancer clinical trials registered by March 2018. Industry and the National Institutes of Health (NIH) were major sponsors, with radiation, surgery, and EGFR inhibitors as common interventions.

Area of Science:

  • Oncology
  • Clinical Research
  • Biostatistics

Background:

  • Lung cancer remains a leading cause of cancer-related mortality globally.
  • Numerous clinical trials are investigating novel interventions across various stages of lung cancer.
  • Understanding the landscape of ongoing research is crucial for advancing treatment strategies.

Purpose of the Study:

  • To compile a comprehensive portfolio of active, open, and recruiting lung cancer clinical trials.
  • To analyze the characteristics of these trials, including phase, sponsorship, location, and interventions.
  • To provide an overview of the current clinical trial landscape for lung cancer.

Main Methods:

  • Data from ClinicalTrials.gov were systematically downloaded for all registered lung cancer trials up to March 2018.
  • A total of 6092 trials were included in the analysis.
  • Descriptive statistics were used to characterize trial phases, sponsors, study locations, and interventions.

Main Results:

  • Phase II trials constituted the largest proportion (48.7%) of lung cancer studies.
  • Industry was the predominant sponsor (41.3%), followed by the National Institutes of Health (NIH) (12.3%).
  • The majority of trials were multicenter (47.9%) and primarily conducted in the USA (50.9%). Radiation (26%), surgery (22%), and EGFR inhibitors (17%) were the most common interventions.

Conclusions:

  • The analysis offers a detailed snapshot of the lung cancer clinical trial landscape as of March 2018.
  • Industry and government funding significantly drive lung cancer research.
  • Radiation, surgery, and targeted therapies like EGFR inhibitors are central to current treatment investigations.
Keywords:
chemotherapyclinical trialsclinicaltrials.govlung cancerlung cancer patents

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