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Fermentation is a crucial anaerobic metabolic process that enables microbes to derive energy from sugar without relying on oxygen or an electron transport chain. This process is fundamental to various biological and industrial applications and is classified based on the metabolic products generated.Role of Pyruvate in FermentationPyruvate and its derivatives serve as key electron acceptors in fermentative pathways. The oxidation of NADH to regenerate NAD+ is essential for the continuation of...
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Genetic Engineering of an Unconventional Yeast for Renewable Biofuel and Biochemical Production
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[Metabolic engineering tools for Saccharomyces cerevisiae].

Lihong Jiang1,2, Chang Dong1,2, Lei Huang1

  • 1Key Laboratory of Biomass Chemical Engineering, Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, Zhejiang, China.

Sheng Wu Gong Cheng Xue Bao = Chinese Journal of Biotechnology
|June 4, 2021
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Summary

Metabolic engineering of Saccharomyces cerevisiae (S. cerevisiae) has advanced significantly over 30 years, creating microbial cell factories. Emerging technologies like synthetic biology enhance its application in producing valuable compounds.

Keywords:
Saccharomyces cerevisiaegenome evolutionmetabolic engineeringsynthetic biologysystems biology

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Area of Science:

  • Metabolic Engineering
  • Synthetic Biology
  • Biotechnology

Background:

  • Metabolic engineering has rapidly developed over the past 30 years since its inception in the early 1990s.
  • Saccharomyces cerevisiae (S. cerevisiae) is a key microbial chassis extensively engineered into cell factories.
  • These engineered S. cerevisiae strains are utilized for producing bulk chemicals and high-value bioactive compounds.

Purpose of the Study:

  • To review the significant technological advancements in metabolic engineering of S. cerevisiae over the last three decades.
  • To provide an overview of classical and modern approaches in S. cerevisiae metabolic engineering.
  • To discuss future prospects for S. cerevisiae metabolic engineering in light of emerging technologies.

Main Methods:

  • Review of classical metabolic engineering tools and strategies.
  • Examination of systems metabolic engineering approaches.
  • Analysis of synthetic biology-driven metabolic engineering methodologies.

Main Results:

  • Detailed summary of 30 years of technological development in S. cerevisiae metabolic engineering.
  • Integration of synthetic biology, bioinformatics, and machine learning in metabolic engineering.
  • Demonstration of S. cerevisiae as a versatile platform for chemical and bioactive compound production.

Conclusions:

  • S. cerevisiae metabolic engineering has matured significantly, driven by technological innovation.
  • The convergence of multiple disciplines is accelerating the development and application of metabolic engineering.
  • Future research should focus on leveraging state-of-the-art technologies for enhanced S. cerevisiae cell factory capabilities.