Related Experiment Video

Updated: Nov 3, 2025

Digital Planimetry for Assessing Wound Closure Kinetics in a Mouse Model
07:56

Digital Planimetry for Assessing Wound Closure Kinetics in a Mouse Model

Published on: January 10, 2025

850

Retraction

    Journal of Cellular Biochemistry
    |June 4, 2021
    PubMed

    Insights

    This study on long noncoding RNA (lncRNA) taurine-upregulated 1 (TUG1) and its impact on cell injury is retracted due to invalid conclusions. Flaws were found in the experimental methods and presented results.

    Area of Science:

    • Molecular Biology
    • Cell Biology
    • RNA Biology

    Context:

    • Investigated the role of long noncoding RNA taurine-upregulated 1 (lncRNA-TUG1) in cellular injury.
    • Focused on the interaction between lncRNA-TUG1 and microRNA-127 (miR-127).
    • Examined lipopolysaccharide-induced injury in MRC-5 cells.

    Purpose:

    • To explore the protective effects of lncRNA-TUG1 against lipopolysaccharide-induced cell injury.
    • To elucidate the mechanism involving the inhibition of miR-127 by lncRNA-TUG1.

    Summary:

    • The article reported protective impacts of lncRNA-TUG1 against lipopolysaccharide-evoked injury in MRC-5 cells.
    • The proposed mechanism involved the inhibition of microRNA-127 by lncRNA-TUG1.
    • Significant flaws and inconsistencies were identified, rendering the conclusions invalid.

    Impact:

    • The study has been retracted by the journal editors due to methodological and data inconsistencies.
    • The findings presented in the original article are considered invalid.
    • This retraction highlights the importance of rigorous scientific validation and reproducibility.

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