Lignans from Lepidium meyenii and Their Anti-Inflammatory Activities
Yi-Yan Zou1,2, Dai-Wei Wang2, Yong-Ming Yan2
1Guangdong Pharmaceutical University, Guangzhou, 510006, P. R. China.
Chemistry & Biodiversity
|June 4, 2021
Abstract:
Meyeniines A-C (1-3), three new lignans, two known neolignans (4-5), and three known lignans (6-8) were isolated from the rhizomes of Lepidium meyenii. Their structures were identified by comprehensive spectroscopic analyses and computational methods. Compound 1 represents a unique lignan featuring an aromatic ring migration. Compounds 2 and 4-6 were analyzed by chiral HPLC column as enantiomers. Biological evaluation revealed that compound 8 could inhibit IL-6 production in lipopolysaccharide (LPS) induced RAW264.7 cells in a dose-dependent manner.
