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Related Experiment Videos

Bone mineral content in normal UK subjects.

J E Compston1, W D Evans, E O Crawley

  • 1Department of Pathology, University of Wales Hospital and College of Medicine, Cardiff.

The British Journal of Radiology
|July 1, 1988
PubMed
Summary

Bone mineral content declines with age in British adults. Radial bone mineral content correlates with height and weight, but spinal bone mineral content does not. British subjects had lower bone density than US subjects.

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Area of Science:

  • Orthopedics
  • Radiology
  • Gerontology

Background:

  • Bone mineral content (BMC) is crucial for skeletal health.
  • Age-related bone loss affects both men and women.
  • Establishing normative data is essential for diagnosing bone density disorders.

Purpose of the Study:

  • To measure bone mineral content in British adults.
  • To investigate correlations between BMC, age, height, and weight.
  • To compare British BMC data with US-based normative data.

Main Methods:

  • Quantitative computed tomography (QCT) and single-photon absorptiometry (SPA) were used.
  • Bone mineral content was measured in lumbar vertebrae and the radial shaft.
  • 129 healthy British subjects (males and females) participated.

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Main Results:

  • Significant negative correlations between BMC and age were observed at both sites (p < 0.001).
  • Radial shaft BMC correlated positively with height and weight, but this weakened after size correction.
  • Spinal trabecular BMC showed no significant correlation with height or weight.
  • British subjects exhibited lower mean BMC values compared to US reference data.

Conclusions:

  • Age is a significant factor in bone mineral content reduction.
  • Body size influences radial bone density, but not spinal trabecular bone density.
  • Local normative data are critical for accurate patient assessment and diagnosis.