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[Microscopic polyangiitis induced by a serotonin reuptake inhibitor. Case report]
Kaoutar Sebti1, Anissa Benjaafar1, Tarik Bouattar1
1Service de néphrologie, dialyse et transplantation rénale, CHU Ibn Sina, Avenue Abderrahim-Bouabid, Faculté de médecine et de pharmacie, Université Mohammed V de Rabat, impasse Souissi, 10100 Rabat, Maroc.
Microscopic polyangiitis, an ANCA-associated vasculitis, can affect multiple organs. This case highlights a potential link between SSRI use and vasculitis, with successful treatment using corticosteroids and cyclophosphamide.
Area of Science:
- Nephrology
- Rheumatology
- Neurology
Background:
- Microscopic polyangiitis (MPA) is a small-vessel vasculitis associated with anti-neutrophil cytoplasmic antibodies (ANCA).
- MPA commonly affects the kidneys, lungs, and skin, but neurological involvement can also occur.
Observation:
- A 31-year-old patient presented with renal, skin, and neurological manifestations suggestive of MPA.
- The patient's symptoms possibly emerged following the initiation of a selective serotonin reuptake inhibitor (SSRI).
Findings:
- Induction therapy with corticosteroids and cyclophosphamide led to complete renal recovery.
- Neurological recovery was gradual but satisfactory.
Implications:
- This case suggests a potential association between SSRI use and the development of MPA.
- Early diagnosis and aggressive immunosuppressive therapy are crucial for managing MPA and improving patient outcomes.
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