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Understanding and countering opioid-induced respiratory depression

Jordan T Bateman1, Sandy E Saunders1, Erica S Levitt1,2

  • 1Department of Pharmacology & Therapeutics, University of Florida, Gainesville, Florida, USA.

British Journal of Pharmacology
|June 5, 2021
PubMed
Summary

Opioid overdose causes fatal respiratory depression through poorly understood mechanisms. This review details opioid effects on breathing, exploring tolerance and new therapies beyond naloxone to improve overdose treatment.

Keywords:
addictionbrainstemcontrol of breathingelectrophysiologymu opioid receptoropioidsrespiratory pharmacology

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