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Life-threatening PPHN refractory to nitric oxide: proposal for a rational therapeutic algorithm

Feriel Fortas1, Matteo Di Nardo2, Nadya Yousef1

  • 1Division of Pediatrics and Neonatal Critical Care, Service de Réanimation Néonatale Hôpital "A.Béclère" Medical Center, Paris Saclay University Hospitals, APHP, 157 rue de la Porte de Trivaux, 92140, Clamart, Paris, France.

European Journal of Pediatrics
|June 6, 2021
PubMed
Summary

A new algorithm guides treatment for persistent pulmonary hypertension of the neonate (PPHN) unresponsive to inhaled nitric oxide. It leverages updated pathobiology and pharmacology for better neonatal critical care outcomes.

Keywords:
EndothelinPhosphodiesteraseProstacyclinProstaglandinPulmonary hypertension

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