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Piperine treating sciatica through regulating inflammation and MiR-520a/P65 pathway.

Jiu-Wang Yu1, Sha Li2, Li-Dao Bao2

  • 1Department of Pharmacy, Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010059, China; Mongolia Medical School, Inner Mongolia Medical University, Hohhot 010110, China.

Chinese Journal of Natural Medicines
|June 7, 2021
PubMed
Summary
This summary is machine-generated.

Piperine alleviates sciatica by regulating miR-520a and P65. This mechanism reduces pro-inflammatory cytokines and enhances anti-inflammatory factors, offering a novel therapeutic approach for sciatica.

Keywords:
Inflammatory factorP65PiperineSciaticamiR-520a

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Area of Science:

  • Neuroscience
  • Molecular Biology
  • Pharmacology

Background:

  • Sciatica etiology is unclear, but inflammatory factors are implicated.
  • Piperine, from Piper nigrum, exhibits anti-inflammatory and analgesic properties.

Purpose of the Study:

  • To investigate the regulatory relationship between miR-520a and P65.
  • To explore how piperine, via miR-520a/P65, modulates cytokine levels for sciatica treatment.

Main Methods:

  • ELISA for inflammatory factors (IL-1β, TNF-α, IL-10, TGF-β1).
  • Microarray for miRNA screening (miR-520a).
  • Bioinformatics for target identification (P65).
  • Real-time PCR, Western blot, HE staining, immunohistochemistry, and dual-luciferase reporter assay.

Main Results:

  • Piperine treatment repaired nerve fibers and reduced inflammation in a rat sciatica model.
  • Piperine upregulated miR-520a, which directly targeted P65, decreasing its expression.
  • Downregulation of P65 led to reduced pro-inflammatory cytokines (IL-1β, TNF-α) and increased anti-inflammatory cytokines (IL-10, TGF-β1).

Conclusions:

  • Piperine demonstrates significant analgesic effects in sciatica via the miR-520a/P65 pathway.
  • This pathway modulates inflammatory cytokine balance, suggesting a therapeutic strategy for sciatica.