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Restless legs syndrome in systemic lupus erythematosus: A case-control study
Cristian Falup-Pecurariu1,2, Anca Enache2,3, Liliana Duca4
1Department of Neurology, County Emergency Clinic Hospital, 500365 Brasov, Romania.
Experimental and Therapeutic Medicine
|June 7, 2021
Summary
Restless Legs Syndrome (RLS) affects a significant portion of patients with Systemic Lupus Erythematosus (SLE), leading to poorer sleep quality. This study found RLS is more prevalent in SLE patients compared to controls.
Area of Science:
- Rheumatology
- Sleep Medicine
- Neurology
Background:
- Sleep disturbances are common in Systemic Lupus Erythematosus (SLE) but not fully understood.
- Restless Legs Syndrome (RLS) is a frequent sleep disorder observed in SLE patients.
Purpose of the Study:
- To determine the prevalence and characteristics of RLS in patients with SLE.
- To compare RLS occurrence and severity between SLE patients and a healthy control group.
Main Methods:
- A prospective case-control study involving 26 SLE patients and 26 age/sex-matched controls.
- Diagnosis of RLS based on International RLS Study Group (IRLSSG) criteria.
- Utilized standardized questionnaires for demographic data, medical history, and validated sleep assessment tools.
Main Results:
- RLS prevalence was significantly higher in the SLE group (34.2%) compared to the control group (7.69%).
- In most SLE patients with RLS (8/9), symptoms began after SLE diagnosis.
- SLE patients with RLS reported moderate to mild severity, with overall poorer sleep quality compared to controls.
Conclusions:
- RLS is more prevalent in patients with SLE.
- The presence of RLS contributes to diminished sleep quality in SLE patients.
- Further investigation into the relationship between SLE and RLS is warranted.
Keywords:
Epworth sleepiness scalePittsburgh sleep quality indexrestless legs syndromesleep disturbancessystemic lupus erythematosusMore Related Videos
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