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Updated: Nov 2, 2025
Author Spotlight: Advancing Early Detection and Treatment of Gastrointestinal Tumors
Published on: February 16, 2024
Type I Gastric Neuroendocrine Tumor Presenting as Acute Upper Gastrointestinal Bleed
Anusha Bapatla1, Ameena Syed1, Abu Fazal Shaik Mohammed1
1Internal Medicine, Wayne State University, Detroit Medical Center (DMC) Sinai Grace Hospital, Detroit, USA.
Abstract:
Gastric neuroendocrine tumors (GNETs) are rare and subdivided into type I, type II, and type III. Types I and II are gastrin-dependent and are usually benign, whereas type III is gastrin-independent and more aggressive. Type I accounts for 70-80% of all GNETs. Most of them are asymptomatic and incidentally detected on endoscopy. It can sometimes present with iron and B12 deficiency, dyspepsia, and less commonly with an upper GI bleed. We present a case of type I GNET who came to the hospital with melena and esophagogastroduodenoscopy (EGD) showing a 3-cm bleeding polyp and histopathology revealing a well-differentiated neuroendocrine tumor with angioinvasion.
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