Related Experiment Video
Updated: Nov 2, 2025
03:57
Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
Published on: July 14, 2023
2.1K
Lithium-Associated Hyperparathyroidism Followed by Catatonia.
Srinagesh Mannekote Thippaiah1, Rachel E Fargason1,2, Jayasudha G Gude1,3
1Valleywise Behavioral Health- Maryvale, 5102 W Campbell Ave, Phoenix, Arizona.
AACE Clinical Case Reports
|June 7, 2021
Summary
Lithium treatment can cause prolonged hyperparathyroidism and hypercalcemia. This case highlights a rare instance of catatonia developing in a patient with lithium-associated hyperparathyroidism, suggesting a link between the two conditions.
Area of Science:
- Endocrinology
- Psychiatry
- Pharmacology
Background:
- Lithium is a common mood stabilizer for bipolar disorder and schizoaffective disorder.
- Adverse effects of lithium on parathyroid function are less commonly recognized.
- Hyperparathyroidism and hypercalcemia are potential, though infrequent, side effects of lithium therapy.
Observation:
- A patient with schizoaffective disorder developed hyperparathyroidism and hypercalcemia during lithium treatment.
- Following lithium discontinuation, the patient exhibited new-onset catatonia, including mutism and posturing.
- Hypercalcemia persisted for six weeks despite lithium cessation.
Findings:
- Laboratory tests confirmed elevated parathyroid hormone (PTH) and calcium levels.
- Treatment with cinacalcet normalized serum calcium, while clozapine and electroconvulsive therapy improved psychiatric symptoms.
- PTH levels normalized after 82 days, indicating prolonged parathyroid dysfunction.
Implications:
- This case underscores the importance of monitoring parathyroid function in patients on lithium.
- Catatonia may be an underrecognized manifestation of lithium-associated hypercalcemia.
- Further research is needed to elucidate the relationship between lithium, hypercalcemia, and catatonia.
Keywords:
ECT, electroconvulsive therapyPTH, parathyroid hormonecatatoniahypercalcemiahyperparathyroidismlithiumMore Related Videos
07:13Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation
Published on: March 14, 2017
14.9K
07:12Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging
Published on: August 17, 2022
4.1K
Related Concept Videos
01:24Mania and Antimanic Drugs: Overview
396
Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as...
396
01:30Electroconvulsive Therapy
326
Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early...
326
01:28Antihypertensive Drugs: Potassium-Sparing Diuretics
1.8K
Liddle syndrome is a genetically inherited form of hypertension characterized by the overactivity of epithelial sodium channels in the nephron, the functional unit of the kidney. This heightened activity leads to increased sodium reabsorption and excessive excretion of potassium. To counteract this, potassium-sparing diuretics such as amiloride are used. They function by blocking these sodium channels, thereby reducing the influx of sodium into the epithelial cells and minimizing the loss of...
1.8K
00:59The Parathyroid Glands
3.2K
The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
3.2K
01:30Positive Symptoms of Schizophrenia: Hallucinations and Delusions
254
Schizophrenia is a complex mental health disorder that can manifest with various positive symptoms, including thought, movement, and behavior disorders. These symptoms significantly disrupt cognitive and motor functions, leading to profound effects on an individual's ability to engage with the world.
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes...
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes...
254
01:26Psychosis: Goals of Pharmacotherapy
299
Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
299