Comparison of the Acinetobacter baumannii Reference Strains ATCC 17978 and ATCC 19606 in Antimicrobial Resistance
K Lucaßen1, S Gerson1, K Xanthopoulou1,2
1Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Cologne, Germany.
Antimicrobial Agents and Chemotherapy
|June 7, 2021
Abstract:
The Acinetobacter baumannii RND efflux pump AdeABC is regulated by the 2-component regulator AdeRS. In this study, we compared the regulation and expression of AdeABC of the reference strains ATCC 17978 and ATCC 19606. A clearly stronger efflux activity was demonstrated for ATCC 19606. An amino acid substitution at residue 172 of adeS was identified as a potential cause for differential expression of the pump. Therefore, we recommend caution with exclusively using single reference strains for research.
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