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Published on: December 19, 2020
COVID-19 pneumonia on chest X-rays: Performance of a deep learning-based computer-aided detection system
Eui Jin Hwang1,2, Ki Beom Kim3, Jin Young Kim4
1Department of Radiology, Seoul National University College of Medicine, Seoul, Korea.
A computer-aided detection (CAD) system shows radiologist-level performance in identifying COVID-19 pneumonia on chest X-rays (CXRs). This CAD tool significantly improves non-radiologist physicians' diagnostic accuracy, aiding triage in resource-limited settings.
Area of Science:
- Medical Imaging
- Artificial Intelligence in Healthcare
- Infectious Disease Diagnostics
Background:
- Chest X-rays (CXRs) are crucial for triaging Coronavirus disease (COVID-19) patients, especially in resource-constrained areas.
- Computer-aided detection (CAD) systems can assist in identifying pneumonia on CXRs where radiologists are scarce.
- Limited research exists on the performance of CAD for COVID-19 and associated pneumonia detection using CXRs.
Purpose of the Study:
- To evaluate the performance of a commercialized, regulatory-approved CAD system in identifying COVID-19 and pneumonia on CXRs.
- To compare the CAD system's performance against expert radiologists and non-radiologist physicians.
- To assess the impact of CAD assistance on the diagnostic performance and inter-reader agreement of physicians.
Main Methods:
- Retrospective collection of CXRs from patients with and without COVID-19 confirmed by RT-PCR.
- Analysis of CXRs using a commercial CAD system and interpretation by 5 thoracic radiologists and 5 non-radiologist physicians.
- Performance evaluation using area under the receiver operating characteristic curves (AUCs) with RT-PCR and chest CT as references.
Main Results:
- The CAD system achieved radiologist-level performance (AUCs of 0.714 vs. RT-PCR, 0.790 vs. CT), outperforming non-radiologist physicians (AUCs of 0.584-0.650).
- Non-radiologist physicians demonstrated significantly improved diagnostic performance when assisted by the CAD (AUCs improved to 0.664-0.738).
- CAD assistance also enhanced inter-reader agreement among physicians (Fleiss' kappa coefficient increased from 0.209 to 0.322).
Conclusions:
- The CAD system demonstrates radiologist-level accuracy in detecting COVID-19 and associated pneumonia on CXRs.
- CAD assistance significantly boosts the diagnostic capabilities of non-radiologist physicians.
- This CAD technology offers a valuable tool for supporting physicians and enabling image-based triage of COVID-19 patients in underserved regions.
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