Related Experiment Video

Updated: Nov 2, 2025

Real-time Live-cell Flow Cytometry to Investigate Calcium Influx, Pore Formation, and Phagocytosis by P2X7 Receptors in Adult Neural Progenitor Cells
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Real-time Live-cell Flow Cytometry to Investigate Calcium Influx, Pore Formation, and Phagocytosis by P2X7 Receptors in Adult Neural Progenitor Cells

Published on: April 3, 2019

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P2X7 receptor in multifaceted cellular signalling and its relevance as a potential therapeutic target in different

Abtar Mishra1, Assirbad Behura1, Ashish Kumar1

  • 1Laboratory of Mycobacterial Immunology, Department of Life Science, National Institute of Technology, Rourkela-769008, Odisha, India.

European Journal of Pharmacology
|June 7, 2021
PubMed

Insights

The P2X7 receptor, a key ATP-activated ion channel, is implicated in numerous physiological functions and diseases like cancer and arthritis. Targeting this receptor offers a promising therapeutic strategy for various inflammatory conditions.

Area of Science:

  • Cellular and Molecular Biology
  • Immunology
  • Pharmacology

Background:

  • The P2X7 receptor is a widely expressed purinergic receptor involved in cellular signaling.
  • It functions as an ATP-gated cation channel, regulating ion flux (Ca2+, Na+, K+).
  • The receptor is upregulated in various diseases, including cancer, diabetes, arthritis, and inflammatory conditions.

Purpose of the Study:

  • To review the structural and functional aspects of the P2X7 receptor.
  • To emphasize the receptor's role in diverse pathophysiological conditions.
  • To provide knowledge for developing targeted therapeutic strategies.

Main Methods:

  • Literature review of existing studies on P2X7 receptor structure and function.
  • Analysis of the receptor's involvement in physiological and pathophysiological processes.
  • Synthesis of information on downstream signaling pathways.

Main Results:

  • The P2X7 receptor participates in crucial processes like cytokine secretion, inflammasome activation, and cell death.
  • Its dysregulation is linked to significant diseases, highlighting its pathological relevance.
  • Understanding receptor architecture and signaling is key to therapeutic development.

Conclusions:

  • The P2X7 receptor is a significant therapeutic target for numerous diseases.
  • Further research into its structure and signaling pathways can lead to novel treatments.
  • Targeting P2X7 offers a promising avenue for improving human health.
Keywords:
CalciumCation channelNLRP3 inflammasomeP2X7 receptorPurino-receptor

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