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Synthesis of Strong Adhesive Hydrogel, Gelatin O-Nitrosobenzaldehyde

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Engineering nanocomposite hydrogels using dynamic bonds.

Cheng-Hsun Lu¹, Cheng-Hsuan Yu¹, Yi-Cheun Yeh¹

¹Institute of Polymer Science and Engineering, National Taiwan University, Taipei, Taiwan.

Acta Biomaterialia

|June 7, 2021

Summary

This review explores nanocomposite (NC) hydrogels utilizing dynamic bonds for enhanced self-healing and stimulus-responsive properties. These advanced biomaterials offer versatile applications in drug delivery, biosensing, and tissue engineering.

Keywords:

Dynamic bonds Nanocomposite hydrogels Self-healing Stimuli-responsiveness

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Last Updated: Nov 2, 2025

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Manufacturing of Three-dimensionally Microstructured Nanocomposites through Microfluidic Infiltration

Manufacturing of Three-dimensionally Microstructured Nanocomposites through Microfluidic Infiltration

Published on: March 12, 2014

Area of Science:

Materials Science
Biomedical Engineering
Polymer Chemistry

Background:

Nanocomposite (NC) hydrogels are versatile biomaterials for drug delivery, biosensors, imaging, and tissue engineering.
Current NC hydrogel development involves various strategies to control structure and properties.

Purpose of the Study:

To review NC hydrogels synthesized using dynamic bonds (covalent and non-covalent).
To highlight the role of dynamic bonds in conferring self-healing and stimulus-responsive properties.
To discuss the impact of dynamic bonds on particle interactions within the hydrogel network.

Main Methods:

Review of literature on NC hydrogels incorporating dynamic covalent bonds (Schiff base, boronate ester) and non-covalent bonds (hydrogen bonds, metal-ligand coordination).
Analysis of material design, fabrication, properties, and applications of representative examples.
Focus on the synergistic effects of nanoparticles and dynamic bonds.

Main Results:

Dynamic bonds enable reversible network formation, leading to self-healing and tunable stimulus-responsiveness in NC hydrogels.
The interface interactions (polymer-polymer, polymer-particle) dictate particle roles as fillers or crosslinkers.
NC hydrogels with dynamic bonds exhibit enhanced properties like multi-functionality and responsiveness for advanced applications.

Conclusions:

NC hydrogels utilizing dynamic bonds represent a significant advancement in biomaterial design.
These materials offer tunable properties and functionalities for diverse biomedical applications.
Future research directions focus on developing next-generation hydrogels with sophisticated dynamic features.