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Author Spotlight: Investigating the Key Factors of Obliterative Bronchiolitis After Lung Transplantation
Published on: November 10, 2023
Post-infectious bronchiolitis obliterans in children: Clinical and radiological evaluation and long-term results
Hakan Yazan1, Fathouma Khalif2, Lina Al Shadfaan1
1Division of Pediatric Pulmonology, Faculty of Medicine, Bezmialem Vakif University, İstanbul, Turkey.
Insights
Persistent infantile obliterative bronchiolitis (PIBO) treatment shows significant clinical and radiological improvements in children. This study highlights positive outcomes for PIBO patients, improving lung function and HRCT findings.
Area of Science:
- Pediatric Pulmonology
- Radiology
- Clinical Medicine
Background:
- Persistent Infantile Obliterative Bronchiolitis (PIBO) is a significant pediatric respiratory condition.
- Understanding clinical and radiological findings is crucial for effective management.
Purpose of the Study:
- To evaluate clinical and radiological findings in children with PIBO.
- To assess treatment outcomes for patients diagnosed with PIBO.
Main Methods:
- Enrolled 114 children diagnosed with PIBO.
- Assessed demographic and clinical characteristics.
- Compared pre- and post-treatment clinical and radiological findings.
Main Results:
- The median age at diagnosis was 17.5 months; persistent wheezing was common.
- 82.5% of patients experienced clinical improvement.
- Significant improvements were noted in HRCT findings (bronchiectasis, atelectasis, hyperinflation, air trapping) and Bhalla scores (8.3 to 6.5, p=0.001).
Conclusions:
- Treatment for PIBO leads to significant improvements in both clinical and radiological outcomes.
- This study contributes valuable data to the limited literature on PIBO management.
Background And Objective:
This study aims to evaluate clinical and radiological findings and treatment outcomes of the patients with PIBO.
Methods:
One hundred fourteen children were enrolled. Initial demographic and clinical findings were evaluated. Pre- and post-treatment clinical and radiological findings were compared.
Results:
The median age of the patients at initial pulmonary injury was 7,2 months, the median age at diagnosis was 17.5 months. Persistent wheezing was the most common complaint. Thirty-five patients had mechanical ventilation history. 82,5% of patients had clinical improvement. Bronchiectasis, atelectasis, hyperinflation and air trapping in HRCT improved significantly with treatment. Post-treatment Bhalla scores decreased from 8.3 to 6.5 (p= 0,001). Improvement was observed in radiological and clinical findings after treatment.
Conclusions:
This study is one of the largest studies in the literature and one of the few studies that evaluate clinical and radiological outcomes of patients with PIBO.
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