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Updated: Nov 2, 2025
Hippocampal Neuronal Cultures to Detect and Study New Pathogenic Antibodies Involved in Autoimmune Encephalitis
Published on: June 2, 2022
Epidemiology of neuronal surface antibody-mediated autoimmune encephalitis and antibody-based diagnostics
Luigi Zuliani1, Sabrina Marangoni2, Piera De Gaspari3
1Department of Neurology, Ospedale San Bortolo, Azienda ULSS8 Berica, Via Rodolfi 37, 36100 Vicenza, Italy; Neuroimmunology Group, Pediatric Research Institute "Città della Speranza", Padova, Italy.
Abstract:
Epidemiologic data on neuronal surface antibody (NSAb)-associated autoimmune encephalitides (NSAE) are scarce and heterogeneous. We review our 13-year-long biobank-data collection and provide the incidence of NSAE in two Italian provinces (approx. Population of 1,400,000) over a 5-year period (July 2013-June 2018). NSAbs were diagnosed in 75 out of 1179 tested patients (6.4%). The most common NSAbs were anti-LGI1 (30 cases), followed by NMDAR (24). Eleven cases of NSAE were diagnosed in Treviso and Trento provinces with an estimated incidence of 1.54 per 1,000,000 population (LGI1-encephalitis 0.84; C.I. 0.38-1.88). LGI1-E is the most frequent NSAE among adults.
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