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Yeast As a Chassis for Developing Functional Assays to Study Human P53
Published on: August 4, 2019
Tumor suppressor p53 regulates intestinal type 2 immunity
Chun-Yuan Chang1, Jianming Wang1, Yuhan Zhao1
1Rutgers Cancer Institute of New Jersey, Rutgers University, New Brunswick, NJ, USA.
Abstract:
The role of p53 in tumor suppression has been extensively studied and well-established. However, the role of p53 in parasitic infections and the intestinal type 2 immunity is unclear. Here, we report that p53 is crucial for intestinal type 2 immunity in response to the infection of parasites, such as Tritrichomonas muris and Nippostrongylus brasiliensis. Mechanistically, p53 plays a critical role in the activation of the tuft cell-IL-25-type 2 innate lymphoid cell circuit, partly via transcriptional regulation of Lrmp in tuft cells. Lrmp modulates Ca2+ influx and IL-25 release, which are critical triggers of type 2 innate lymphoid cell response. Our results thus reveal a previously unrecognized function of p53 in regulating intestinal type 2 immunity to protect against parasitic infections, highlighting the role of p53 as a guardian of immune integrity.
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