Related Experiment Video

Updated: Nov 2, 2025

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
10:46

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

Published on: December 9, 2015

10.8K

The prevalence of COVID-19 infection in patients with multiple sclerosis (MS): a systematic review and meta-analysis

Abdorreza Naser Moghadasi1, Omid Mirmosayyeb2,3, Mahdi Barzegar3

  • 1Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
|June 8, 2021
PubMed
Abstract

Insights

The pooled prevalence of COVID-19 infection in multiple sclerosis (MS) patients is 4%. Hospitalization rates were higher in MS patients with COVID-19, with 10% hospitalized and 4% of those dying.

Area of Science:

  • Epidemiology
  • Infectious Diseases
  • Neurology

Background:

  • COVID-19 prevalence varies globally, necessitating specific population studies.
  • Multiple Sclerosis (MS) is a chronic neurological disease affecting immune responses.
  • Understanding COVID-19 impact on MS patients is crucial for clinical management.

Purpose of the Study:

  • To estimate the pooled prevalence of COVID-19 infection in patients with Multiple Sclerosis (MS).
  • To analyze hospitalization and mortality rates associated with COVID-19 in MS patients.

Main Methods:

  • Systematic review and meta-analysis of studies up to April 2021.
  • Searched multiple databases including PubMed, Scopus, EMBASE, Web of Science, and Google Scholar.
  • Included MeSH and text words for COVID-19 and Multiple Sclerosis (MS) variants.

Main Results:

  • Analyzed 12 articles from an initial 1466, evaluating 101,462 patients.
  • The pooled prevalence of suspected COVID-19 in MS patients was 4% (95% CI: 3-4%).
  • Hospitalization rate was 10% (95% CI: 7-12%), and mortality among hospitalized MS patients was 4% (95% CI: 1-6%).

Conclusions:

  • The overall pooled prevalence of COVID-19 infection among MS patients is estimated at 4%.
  • MS patients with COVID-19 exhibited a higher hospitalization rate compared to the general population.
  • Findings highlight the importance of monitoring and managing COVID-19 in MS patient cohorts.
Keywords:
COVID-19Multiple sclerosisPrevalence

More Related Videos

Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment08:36

Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment

Published on: April 19, 2024

836
Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla08:51

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

Published on: February 19, 2021

9.3K

Related Concept Videos

Prevalence and Incidence01:08

Prevalence and Incidence

In statistical epidemiology and health sciences, two essential metrics—prevalence and incidence—are fundamental for understanding disease dynamics within a population. These measures enable public health officials, epidemiologists, and researchers to assess the burden of diseases, allocate resources effectively, and design impactful public health policies and interventions.
Prevalence indicates the proportion of individuals in a population who have a specific disease or health...
1.0K
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
161
Myasthenia Gravis: Overview and Treatment01:20

Myasthenia Gravis: Overview and Treatment

Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
2.2K
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
13.0K
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies01:27

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
2.7K
Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
140