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Updated: Nov 2, 2025

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks

Published on: June 26, 2020

Equine parvovirus hepatitis.

Anna Sophie Ramsauer¹, Marcha Badenhorst¹, Jessika-M V Cavalleri¹

¹Department for Companion Animals and Horses, University Equine Clinic - Internal Medicine, University of Veterinary Medicine Vienna, Vienna, Austria.

Equine Veterinary Journal

|June 8, 2021

Summary

This summary is machine-generated.

Equine parvovirus hepatitis (EqPV-H) causes severe liver disease in horses, often linked to biological products. This hepatotropic virus is a key cause of Theiler's disease, necessitating its consideration in equine hepatitis diagnoses.

Keywords:

Ungulate copiparvovirus 6 EqPV-H Theiler´s disease horse liver serum hepatitis

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Area of Science:

Veterinary Virology
Equine Pathology
Hepatology

Background:

Equine parvovirus hepatitis (EqPV-H) emerged in 2018, linked to Theiler's disease, a severe equine hepatitis.
EqPV-H is hepatotropic and frequently found in horses with Theiler's disease, characterized by rapid liver failure.

Purpose of the Study:

To investigate the role of EqPV-H in equine hepatitis.
To understand the transmission routes and clinical presentation of EqPV-H infection.

Main Methods:

Identification of EqPV-H in serum and liver tissues of affected horses.
Experimental infection studies to observe viral effects.
Analysis of clinical signs and histopathological findings.

Main Results:

EqPV-H is strongly associated with Theiler's disease, causing hepatocellular necrosis and liver architecture collapse.
Experimental infections often result in subclinical hepatitis, with peak viremia preceding hepatitis onset.
Transmission can occur iatrogenically via biological products or through oral routes; arthropod vectors require further study.

Conclusions:

EqPV-H is a likely causative agent of Theiler's disease in horses.
Veterinarians should consider EqPV-H in differential diagnoses for equine hepatitis.
The risks of equine-origin biological products require emphasis due to potential EqPV-H transmission.