Related Experiment Video
Updated: Jul 19, 2026
Evaluation of T Follicular Helper Cells and Germinal Center Response During Influenza A Virus Infection in Mice
Published on: June 27, 2020
Clinical features and risk factors for severe influenza in children: A study from multiple hospitals in Shanghai
Yu Shi1, Weiming Chen2, Mei Zeng3
1Division of Medical Administration, Children's Hospital of Fudan University, 399 Wan Yuan Road, Shanghai, China.
Insights
Severe influenza in children is a growing concern in China. This study identified key risk factors and complications, including influenza-associated encephalopathy and delayed oseltamivir treatment, highlighting the need for prompt medical attention.
Area of Science:
- Pediatrics
- Infectious Diseases
- Epidemiology
Background:
- Rising incidence and mortality of influenza in children.
- Limited data on severe influenza virus infections in Chinese children.
Purpose of the Study:
- To investigate clinical characteristics and risk factors of severe influenza in children in China.
- To identify predictors of mortality in pediatric influenza cases.
Main Methods:
- Retrospective case-control study.
- Collected clinical data from 36,047 children in Shanghai (June 2014-June 2019).
- Compared severe influenza cases (n=118) with controls.
Main Results:
- Severe influenza cases exhibited higher rates of fever, cough, gastrointestinal symptoms, coma, and epilepsy.
- Complications like pneumorrhagia, heart failure, septic shock, ARDS, and influenza-associated encephalopathy were more frequent in severe cases.
- Decreased hemoglobin, elevated ALT, BUN, and lactate levels were identified as risk factors for mortality.
Conclusions:
- Influenza-associated encephalopathy and ARDS are common in severe pediatric influenza.
- Delayed oseltamivir administration is associated with increased fatality.
Background:
The incidence and mortality of influenza in children had risen, but data are limited on children with severe influenza virus infection in China.
Methods:
We conducted a retrospective case-control study and collected the patients' clinical data. Clinical data including demography, clinical presentation, laboratory findings, radiologic findings, treatment and outcomes were collected. Children were clinically confirmed to have virus infection in Shanghai in three hospitals from June 2014 to June 2019.
Results:
During the study, 36,047 children were enrolled. Among them, 118 met the criteria for severe flu. Clinical symptoms such as fever, cough, gastrointestinal symptoms, coma and epilepsy were higher in the severe group. Complications such as pneumorrhagia, heart failure, septic shock, acute renal failure and influenza-associated encephalitis were higher in the severe influenza group than the death group. The laboratory findings including decreased hemoglobin, high alanine aminotransferase, high urea nitrogen and high lactate levels were risk factors for death in children with influenza.
Conclusion:
Influenza-associated encephalopathy (IAE), acute respiratory distress syndrome (ARDS) were the common clinical manifestations and complications for the severe influenza, and delayed use of oseltamivir was found to be associated with fatality.
More Related Videos
08:10Production of High-Titer Infectious Influenza Pseudotyped Particles with Envelope Glycoproteins from Highly Pathogenic H5N1 and Avian H7N9 Viruses
Published on: January 15, 2020
03:53Development of Multiplex Real-Time RT-qPCR Assays for the Detection of SARS-CoV-2, Influenza A/B, and MERS-CoV
Published on: November 10, 2023
Related Concept Videos
01:27Influenza
01:29Respiratory Syncytial Virus Disease