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Related Concept Videos

Antihypertensive Drugs: Direct Renin Inhibitors01:25

Antihypertensive Drugs: Direct Renin Inhibitors

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The renin-angiotensin-aldosterone system (RAAS) is an intricate physiological pathway involving numerous enzymes and hormones, including renin, angiotensin-converting enzyme (ACE), angiotensin I and II, and aldosterone. Imbalances within this system increase the production of angiotensin II and aldosterone. Increased angiotensin II levels promote vasoconstriction and blood pressure elevation. Concurrently, higher aldosterone levels stimulate sodium and water reabsorption in the kidneys,...
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Heart Failure Drugs: Inhibitors of Renin-Angiotensin System01:26

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

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The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
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Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors01:30

Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors

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Angiotensin-converting enzyme (ACE), a vital component of the renin-angiotensin-aldosterone system, is abundant in lung endothelial cells. ACE converts the inactive decapeptide, angiotensin I, into the active octapeptide, angiotensin II. This potent vasoconstrictor narrows blood vessels, increasing resistance to blood flow and elevating blood pressure. Angiotensin II also stimulates aldosterone production, encouraging kidney cells to reabsorb more sodium and water from urine, thereby increasing...
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Antihypertensive Drugs: Action of β1 Blockers01:17

Antihypertensive Drugs: Action of β1 Blockers

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β1-receptors are primarily located in the heart and kidneys. In cardiac myocytes, these receptors interact with neurotransmitters released by the sympathetic nervous system during heightened activity or danger. As a result, β1-receptors get activated, initiating a series of biochemical processes. Excessive activation of beta receptors due to chronic stress can abnormally increase heart rate and contractility, resulting in high blood pressure or hypertension. To counteract this,...
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Antihypertensive Drugs: Angiotensin II Receptor Blockers01:30

Antihypertensive Drugs: Angiotensin II Receptor Blockers

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In the renin-angiotensin-aldosterone system, a hormone called angiotensin II plays a crucial role. It binds to the AT1 receptors in vascular smooth muscles coupled with Gq proteins. The activation of these receptors activates an enzyme called phospholipase C, which releases two molecules: inositol trisphosphate and diacylglycerol. These molecules cause a chain reaction that leads to the phosphorylation of myosin light chains and promotes interaction between actin and myosin, leading to smooth...
2.0K
Antihypertensive Drugs: Action of Diuretics01:16

Antihypertensive Drugs: Action of Diuretics

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Diuretics are antihypertensive drugs used to treat hypertension resulting from sodium and water retention. Sodium, vital for fluid balance and nerve or muscle function, is regulated by the kidneys through millions of nephrons. Blood enters nephrons via afferent arterioles, which branch into capillaries called glomeruli. These filter blood plasma, allowing water and solutes, like sodium ions, to pass through capillary walls into Bowman's capsule. The filtrate then flows through various...
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Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion
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Renal Denervation in Hypertension.

Usman S Ansari1, Benjamin J Lee2

  • 1Houston Methodist Hospital Houston, Texas United States.

Methodist Debakey Cardiovascular Journal
|June 9, 2021
PubMed
Summary

This article discusses the clinical practices and academic backgrounds of Drs. Benjamin Lee and Usman Ansari. It highlights their expertise in internal medicine and nephrology, contributing to medical research and patient care.

Keywords:
hypertensionrenal denervation

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Area of Science:

  • Internal Medicine
  • Nephrology
  • Clinical Research

Background:

  • Dr. Benjamin Lee is an Assistant Professor at Houston Methodist Institute for Academic Medicine and Weill Cornell Medical College.
  • Dr. Lee completed internal medicine residency and nephrology fellowship at UCSF, earning a Master of Advanced Study in Clinical Research.
  • Dr. Usman Ansari is completing his internal medicine residency at Houston Methodist after earning his Doctor of Osteopathy.

Purpose of the Study:

  • To introduce the authors and their credentials.
  • To highlight their contributions to academic medicine and clinical practice.
  • To establish their expertise in internal medicine and nephrology.

Main Methods:

  • N/A - This is an introductory column.
  • N/A - No study methods are described.
  • N/A - Focus is on author background.

Main Results:

  • N/A - This is an introductory column.
  • N/A - No study results are presented.
  • N/A - Focus is on author background.

Conclusions:

  • Drs. Lee and Ansari possess extensive training and experience in internal medicine and nephrology.
  • Their backgrounds in clinical research and academic medicine suggest potential for future contributions.
  • They are positioned to provide valuable insights in their respective fields.