Prothrombinase: the paradigm for membrane bound enzyme complexes; a memoir
1Professor Emeritus, College of Medicine, University of Vermont, Burlington, VT, USA. kgmann1@comcast.net.
Journal of Thrombosis and Thrombolysis
|June 9, 2021
Summary
This review details the Prothrombinase complex paradigm's history and its integration into the extrinsic pathway. It highlights key research efforts and contributors from 1968 to 2012.
Area of Science:
- Biochemistry
- Hematology
- Molecular Biology
Background:
- The Prothrombinase complex is crucial for blood coagulation.
- Understanding its development and pathway integration is vital for hemostasis research.
Purpose of the Study:
- To review the historical development of the Prothrombinase complex paradigm.
- To examine its incorporation into the extrinsic pathway of coagulation.
- To summarize key research contributions from 1968-2012.
Main Methods:
- Historical review of scientific literature.
- Summary of laboratory research findings.
- Identification of key researchers and their contributions.
Main Results:
- The Prothrombinase complex paradigm has evolved significantly.
- Its role within the extrinsic pathway has been clarified through extensive research.
- Numerous scientific contributions have shaped current understanding.
Conclusions:
- The Prothrombinase complex is integral to the extrinsic pathway.
- Decades of research have elucidated its function and development.
- This review consolidates historical perspectives and key findings.
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