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[Neurodevelopmental disorders modify neurodegenerative diseases: a medical history to screen in memory clinic]
Eloi Magnin1, Julie Monnin2, Sylvie Chokron3
1Centre Mémoire Ressources et Recherche (CMRR), Centre Expert Parkinson (CEP), Service de neurologie, CHRU de Besançon, France, Neurosciences intégratives et cliniques EA481, Université Bourgogne - Franche-Comté, Besançon, France, Commission GREDEVad (Groupe de Réflexion sur l'Évaluation des troubles neuroDEVeloppmentaux adulte) au sein du GRECO (Groupe de Réflexion sur l'Évaluation Cognitive).
Abstract:
Neurodevelopmental disorders are frequent in the general population and are often lifelong conditions despite sometimes being masked by conscious or unconscious compensation and avoidance mechanisms. These conditions are often unknown or underestimated in adults, even when diagnosed in childhood. Neurodevelopmental disorders share similarities with and frequently interact in a complex way with neurodegenerative disorders. Considering these aspects during memory clinic assessments can provide a new perspective on lifelong neurocognitive trajectories. Assessing both neurodevelopmental and neurodegenerative dimensions is challenging but should improve diagnostic accuracy. It is therefore necessary to understand the lifelong specific neurocognitive trajectory of each patient in order to develop personalized and focused cognitive medicine and care.
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