Amyloidosis with Cardiac Involvement: Identification, Characterization, and Management
Faizi Jamal1, Michael Rosenzweig2
1Department of Medicine, Division of Cardiology, City of Hope, Duarte, CA, USA.
Current Hematologic Malignancy Reports
|June 9, 2021
Summary
Cardiac amyloidosis diagnosis and management are improving with new imaging tools and treatments for light chain and transthyretin amyloidosis, enhancing patient survival and organ response.
Area of Science:
- Cardiology
- Oncology
- Genetics
Background:
- Amyloidosis involves abnormal protein deposits causing organ dysfunction.
- Cardiac amyloidosis significantly impacts prognosis and treatment strategies.
- Accurate disease characterization is crucial for effective patient management.
Purpose of the Study:
- To review advancements in diagnosing and managing cardiac amyloidosis.
- To highlight the importance of understanding precursor proteins and organ involvement.
- To discuss new therapeutic options for light chain and transthyretin amyloidosis.
Main Methods:
- Review of recent imaging modalities for detecting cardiac amyloid infiltration.
- Analysis of diagnostic algorithms for suspected amyloidosis.
- Evaluation of outcomes from novel treatments for specific amyloidosis types.
Main Results:
- New imaging techniques enhance the identification of cardiac amyloidosis.
- Diagnostic algorithms aid in disease classification and genetic testing.
- Emerging therapies improve survival and organ response in light chain and transthyretin amyloidosis.
Conclusions:
- Advanced imaging and diagnostic tools improve cardiac amyloidosis detection and management.
- Novel treatments offer improved outcomes for patients with specific amyloidosis types.
- Continued research is vital for addressing the morbidity and mortality associated with systemic amyloidosis.
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