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Maternal nutrition during development programs male reproductive aging. Both over- and undernutrition accelerate reproductive aging, but exercise can mitigate these effects in offspring.

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Area of Science:

  • Reproductive biology
  • Developmental programming
  • Aging research

Background:

  • Developmental programming influences adult health, including metabolic, behavioral, and reproductive functions.
  • Aging is also influenced by developmental programming, with limited research on maternal nutrition's impact on male reproductive aging.

Purpose of the Study:

  • To review the effects of fetal exposure to maternal environmental challenges on male offspring fertility and reproductive aging.
  • To explore key factors in male reproductive aging, including hormonal changes, DNA fragmentation, oxidative stress, telomere shortening, epigenetics, and maternal lifestyle/nutrition.

Main Methods:

  • Review of existing literature on developmental programming and male reproductive aging.
  • Focus on factors like hormone production, DNA damage, oxidative stress, telomere length, epigenetics, and maternal factors.

Main Results:

  • Male reproductive aging is developmentally programmed.
  • Maternal over- or undernutrition accelerates male reproductive aging via decreased testosterone, increased oxidative stress, and altered sperm quality.
  • Exercise in offspring of obese mothers can improve adverse programming effects.

Conclusions:

  • Maternal nutrition significantly impacts male reproductive aging, with both excess and deficiency causing detrimental effects.
  • Transgenerational effects can occur via paternal lines, influenced by seminal fluid.
  • Understanding developmental programming-aging interactions is crucial for male health and future generations.