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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Practical Enzymatic Production of Carbocycles

Weijin Wang1, Douglass F Taber1, Hans Renata2

  • 1Department of Chemistry, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL, 33458, USA.

Chemistry (Weinheim an Der Bergstrasse, Germany)
|June 9, 2021
PubMed
Summary

Enzyme-mediated assembly offers a sustainable and selective alternative to traditional palladium-catalyzed reactions for creating complex carbocycles in medicinal chemistry. This approach is poised to become a practical and affordable method for pharmaceutical development.

Keywords:
alicyclic synthesisbiocatalysiscarbocyclesenzymatic methodsmedicinal chemistry

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