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Updated: Nov 2, 2025

Digital Planimetry for Assessing Wound Closure Kinetics in a Mouse Model
07:56

Digital Planimetry for Assessing Wound Closure Kinetics in a Mouse Model

Published on: January 10, 2025

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Retraction

    Journal of Cellular Biochemistry
    |June 9, 2021
    PubMed

    Insights

    This study on gastric cancer cell growth and migration has been retracted due to significant flaws. The findings regarding microRNA-133a and presenilin 1 are considered invalid by the editors.

    Area of Science:

    • Oncology
    • Molecular Biology
    • Biochemistry

    Context:

    • Gastric cancer remains a significant global health challenge.
    • Understanding the molecular mechanisms regulating gastric cancer progression is crucial for developing effective therapies.

    Purpose:

    • To investigate the role of microRNA-133a in inhibiting gastric cancer cell growth, migration, and epithelial-mesenchymal transition.
    • To identify presenilin 1 as a potential target of microRNA-133a in gastric cancer.

    Summary:

    • The article reported that microRNA-133a inhibits gastric cancer cell proliferation, invasion, and epithelial-mesenchymal transition by targeting presenilin 1.
    • However, the study has been retracted due to identified flaws and inconsistencies between experimental results and methods.
    • The editors deemed the conclusions of the article invalid following an investigation.

    Impact:

    • The retraction invalidates previous findings on microRNA-133a and presenilin 1 in gastric cancer.
    • This highlights the importance of rigorous validation in scientific research and the potential impact of retractions on the scientific record.

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