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Related Concept Videos

Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

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Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
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Cancer02:18

Cancer

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Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
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What is Cancer?02:12

What is Cancer?

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Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
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Cancer Prevention02:59

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Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
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Cancer Vaccines01:30

Cancer Vaccines

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Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
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Metastasis02:30

Metastasis

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Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
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Related Experiment Video

Updated: Nov 2, 2025

Initiation of Metastatic Breast Carcinoma by Targeting of the Ductal Epithelium with Adenovirus-Cre: A Novel Transgenic Mouse Model of Breast Cancer
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Initiation of Metastatic Breast Carcinoma by Targeting of the Ductal Epithelium with Adenovirus-Cre: A Novel Transgenic Mouse Model of Breast Cancer

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Catching viral breast cancer.

James S Lawson1, Wendy K Glenn2

  • 1School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, Australia. james.lawson@unsw.edu.au.

Infectious Agents and Cancer
|June 10, 2021
PubMed
Summary
This summary is machine-generated.

Viruses like MMTV, HPV, and EBV are linked to increased breast cancer risk. Bovine leukemia virus (BLV) also shows potential involvement, suggesting viral infections contribute to human breast cancer development.

Keywords:
Bovine leukemia virusBreast cancerCausationEpstein Barr virusEvidenceHuman papilloma virusMouse mammary tumour virusMultiple virus

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Modeling Breast Cancer via an Intraductal Injection of Cre-expressing Adenovirus into the Mouse Mammary Gland
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Modeling Breast Cancer in Human Breast Tissue using a Microphysiological System
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Modeling Breast Cancer in Human Breast Tissue using a Microphysiological System

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Area of Science:

  • Oncology
  • Virology
  • Epidemiology

Background:

  • Viruses are increasingly recognized as potential contributors to various human cancers.
  • Specific viruses have been investigated for their association with breast cancer development and progression.

Purpose of the Study:

  • To evaluate the association between several viruses and human breast cancer.
  • To explore potential causal mechanisms and transmission routes for these viruses in breast cancer.

Main Methods:

  • Comparative analysis of viral prevalence in breast cancer patients versus control groups.
  • Review of proposed oncogenic mechanisms and transmission pathways for each virus.

Main Results:

  • Mouse mammary tumor virus (MMTV), high-risk human papillomaviruses (HPV), and Epstein-Barr virus (EBV) show significantly higher prevalence in breast cancer tissues.
  • Bovine leukemia virus (BLV) also demonstrates increased prevalence in human breast cancer.
  • Potential transmission routes include saliva (MMTV, EBV), sexual contact (HPV), and consumption of contaminated animal products (BLV).

Conclusions:

  • Compelling evidence suggests MMTV, high-risk HPV, and EBV play causal roles in human breast cancer.
  • BLV is also likely to have a causal role, though evidence is more limited.
  • Understanding viral contributions is crucial for developing novel breast cancer prevention and treatment strategies.