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Understanding the SARS-CoV-2 virus to mitigate current and future pandemic(s)
Swaraj Mohanty1, Subhojit Paul1, Yasmin Ahmad1
1Peptide and Proteomics Division, Defence Institute of Physiology and Allied Sciences (DIPAS), Defence R&D Organization (DRDO), Lucknow Road, Timarpur, Delhi 110054 India.
Virusdisease
|June 10, 2021
Summary
Coronaviridae family member, SARS-CoV-2, causes the COVID-19 pandemic. This review details its transmission, disease mechanisms, symptoms, and control strategies.
Area of Science:
- Virology
- Infectious Diseases
- Molecular Biology
Background:
- Microorganisms, including viruses, are ancient life forms.
- Viruses are obligate intracellular parasites with diverse families like Retroviridae and Coronaviridae.
- Viruses can cause significant human diseases, such as HIV-AIDS and the current COVID-19 pandemic.
Purpose of the Study:
- To review the transmission dynamics of SARS-CoV-2.
- To elucidate the molecular mechanisms of SARS-CoV-2 pathogenesis.
- To summarize clinical manifestations and control strategies for COVID-19.
Main Methods:
- Literature review of scientific databases (PubMed, Google Scholar).
- Information synthesis from reputable health organizations (NIH, WHO, CDC, EMBL, USFDA).
- Data compilation as of May 1, 2021.
Main Results:
- SARS-CoV-2 transmission occurs through respiratory droplets and aerosols.
- The virus hijacks host cell machinery for replication.
- Clinical symptoms range from mild to severe, affecting multiple organ systems.
Conclusions:
- Understanding SARS-CoV-2 transmission and pathogenesis is crucial for effective control.
- Public health interventions and medical strategies are essential to mitigate the pandemic's impact.
- Ongoing research is vital for developing advanced diagnostics, therapeutics, and vaccines.
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