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Antibody response to Campylobacter coli in children during intestinal infection and carriage
P M Martin1, J Mathiot, J Ipero
1Institut Pasteur, Bangui, Central African Republic.
Insights
Antibody responses in children infected with Campylobacter coli mirror those seen with Campylobacter jejuni. This finding aids comparative studies of symptomatic and asymptomatic enteric infections.
Area of Science:
- Microbiology
- Immunology
- Infectious Diseases
Background:
- Campylobacter coli is a significant cause of enteric infections in the Central African Republic, accounting for nearly 40% of Campylobacter isolations.
- Previous research on Campylobacter jejuni infections indicates a specific antibody response pattern.
Purpose of the Study:
- To investigate the antibody response to Campylobacter coli infection in children.
- To compare the antibody response to C. coli with that of C. jejuni.
Main Methods:
- Analysis of antibody responses in children with C. coli infection and carriage.
- Detection of antibodies against glycine-extracted membrane antigens, flagella, and cholera toxin.
Main Results:
- Both C. coli infection and carriage elicited antibodies against membrane antigens, flagella, and cholera toxin.
- The antibody response to C. coli is similar to that observed for C. jejuni.
- Anti-cholera toxin antibodies targeted both the A and B subunits.
Conclusions:
- The antibody response to Campylobacter coli in children shares similarities with Campylobacter jejuni.
- This resemblance facilitates comparative research on symptomatic and asymptomatic Campylobacter infections.
- Understanding these immune responses is crucial for developing diagnostic and therapeutic strategies.
Abstract:
In the Central African Republic, etiological studies of diarrhea have shown that Campylobacter coli accounts for almost 40% of Campylobacter enteric isolations. This prompted us to investigate the antibody response to C. coli infection in children. As expected from the literature on Campylobacter jejuni infections, our results show that both infection and carriage elicited antibodies against glycine-extracted membrane antigens, flagella, and cholera toxin. The human antibody response to C. coli resembles the response to C. jejuni, and this similarity will allow comparative studies on larger numbers of infections, both symptomatic and asymptomatic. Anti-cholera toxin antibodies were directed against both the A and B subunits.