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Updated: Nov 2, 2025
Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
Published on: June 13, 2014
Tumor-Specific Multipath Nucleic Acid Damages Strategy by Symbiosed Nanozyme@Enzyme with Synergistic Self-Cyclic
Yan Zhao1, Weiheng Kong1, Peng Wang1
1State Key Laboratory for Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, Hunan, 410082, China.
Abstract:
The high proliferation efficiency, redox imbalance, and elevated nucleic acid repair capabilities of tumor cells severely restrict the theranostic efficacy. Selectively interference chaotic tumors with devastating nucleic acid damages (NUDs) properties are expected to overcome theranostic barriers. Here, an exquisite catalytic-based strategy with comprehensive NUDs mechanisms is demonstrated. In this regard, enzyme (glucose oxidase, GOD) symbioses nanozyme Cu3+x (PO4 )2 through biomineralization (abbreviated as Cu@GOD), GOD can disorder the metabolism by consuming glucose, thereby inhibiting the nutrition supply for nucleic acid repair. GOD-catalyzed H2 O2 guarantees the self-cyclic glutathione depletion and reactive oxygen species generation caused by Cu3+x (PO4 )2 , resulted the reduced antioxidation defense and enhanced oxidation assault, ensures an indiscriminate NUDs ability. Moreover, the high photothermal effect of Cu3+x (PO4 )2 induces effective tumor inhibition. Consequently, this substantial multipath NUDs strategy, with potentials of suppressing the cytoprotective mechanisms, amplifying the cellular oxidative stress, and disrupting the redox balance to ensure substantial irreversible NUDs, completely breaks the obstacle of chaotic tumors, providing new conceptual thinking for tumor proliferation inhibition.
Insights
This study introduces a novel nanozyme strategy to combat tumor growth by inducing severe nucleic acid damage (NUDs). The approach disrupts tumor metabolism and enhances oxidative stress, offering a new path for cancer theranostics.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Oncology
Background:
- Tumor cells exhibit high proliferation, redox imbalance, and efficient nucleic acid repair, hindering theranostic efficacy.
- Targeting tumor-specific vulnerabilities like nucleic acid damage (NUDs) is crucial for overcoming therapeutic barriers.
Purpose of the Study:
- To develop a catalytic strategy for inducing comprehensive nucleic acid damages (NUDs) in tumor cells.
- To overcome theranostic barriers associated with aggressive tumor proliferation and repair mechanisms.
Main Methods:
- Enzyme (glucose oxidase, GOD) symbioses with nanozyme Cu3+x(PO4)2 via biomineralization to create Cu@GOD.
- Utilizing GOD to consume glucose, inhibit nutrient supply for repair, and catalyze H2O2 generation.
- Leveraging Cu3+x(PO4)2 for glutathione depletion, reactive oxygen species generation, and photothermal effects.
Main Results:
- The Cu@GOD system effectively disorders tumor metabolism and inhibits nucleic acid repair.
- Synergistic action of GOD and Cu3+x(PO4)2 leads to glutathione depletion and enhanced oxidative stress.
- The strategy induces irreversible NUDs, suppresses cytoprotective mechanisms, and amplifies oxidative assault.
Conclusions:
- The developed multipath NUDs strategy effectively inhibits tumor proliferation by disrupting cellular defense and redox balance.
- This approach offers a novel conceptual framework for enhancing tumor theranostics and overcoming therapeutic resistance.
