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Prevalence of allergic fungal sinusitis among patients with nasal polyposis

Rahim Dhanani1, Shayan Khalid Ghaloo1, Basit Salam2

  • 1Department of Surgery, Aga Khan University Hospital, Karachi, Pakistan.

JPMA. the Journal of the Pakistan Medical Association
|June 10, 2021
PubMed
Abstract

Insights

Allergic fungal sinusitis affects nearly a quarter of patients with nasal polyps. These patients exhibit significantly higher Lund-Mackay scores, indicating more severe sinus disease.

Area of Science:

  • Otolaryngology
  • Allergy and Immunology
  • Pathology

Background:

  • Nasal polyps are common, and allergic fungal sinusitis (AFS) is a recognized subtype.
  • Understanding the prevalence and clinical impact of AFS in patients with nasal polyps is crucial for effective management.

Purpose of the Study:

  • To determine the frequency of AFS in patients with nasal polyps.
  • To compare the severity of sinus disease, as measured by Lund-Mackay scores, between patients with and without AFS.

Main Methods:

  • A cross-sectional study involving 114 patients with sinonasal polyposis undergoing surgery at a tertiary healthcare center.
  • AFS diagnosis was based on histopathology (allergic mucin with fungal hyphae) and positive fungal culture.
  • Lund-Mackay scores were assessed, and data analyzed using SPSS 25.

Main Results:

  • 23.7% of patients were diagnosed with allergic fungal sinusitis.
  • A significant association was found between asthma and AFS (p=0.03).
  • Patients with AFS had significantly higher mean Lund-Mackay scores (p<0.01).

Conclusions:

  • Approximately one-fourth of patients with nasal polyps have allergic fungal sinusitis.
  • AFS is associated with more severe sinus disease, as indicated by higher Lund-Mackay scores.
Keywords:
Allergic fungal sinusitis, Frequency, Rhinosinusitis, Lund-Mackay score, Nasal polyp.

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