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The National Cryo-EM Facility at Frederick National Laboratory: Operational Procedures, Methods and Outputs.
Ulrich Baxa1, Thomas J Edwards1, Matt Hutchison1
1Frederick National Laboratory for Cancer Research, Frederick, MD 21701, USA.
Microscopy Today
|June 11, 2021
Summary
The National Cryo-Electron Microscopy Facility (NCEF) offers US cancer researchers free, rapid access to high-resolution cryo-electron microscopy (cryo-EM) data collection. Projects are selected based on screening image quality, not proposals, accelerating cancer biology research.
Area of Science:
- Structural Biology
- Biophysics
- Cancer Research
Background:
- The National Cancer Institute established the National Cryo-Electron Microscopy Facility (NCEF) in May 2017.
- NCEF aims to support US researchers investigating cancer biology.
Purpose of the Study:
- To provide an overview of the NCEF's operations.
- To detail typical data collection procedures.
- To share insights from structures obtained at the facility.
Main Methods:
- Cryo-electron microscopy (cryo-EM) data collection.
- Screening image analysis for project suitability.
- First-come, first-served basis for project selection.
Main Results:
- Overview of NCEF operational procedures.
- Description of standard cryo-EM data collection workflows.
- Presentation of emerging structural insights from collected data.
Conclusions:
- NCEF facilitates rapid access to advanced cryo-EM technology for cancer research.
- The facility's streamlined process accelerates the acquisition of high-resolution structural data.
- Structural data from NCEF contributes to understanding cancer biology.
