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Published on: October 11, 2019
Tfcancer: a manually curated database of transcription factors associated with human cancers
Qingqing Huang1, Zhengtang Tan1, Yanjing Li1
1School of Life Sciences and Engineering, Southwest Jiaotong University, Chengdu 610031, China.
Summary:
Transcription factors (TFs) are critical regulation elements and its dysregulation can lead to a variety of cancers. However, currently, there are no such online resources for large-scale collection, storage and analysis of TF-cancer associations in those cancers. To fill this gap, we present a database called TFcancer (http://lcbb.swjtu.edu.cn/tfcancer/), which contains 3136 experimentally supported associations between 364 TFs and 33 TCGA cancers by manually curating more than 1800 literature. TFcancer mainly concentrates on four aspects: TF expression, molecular alteration, regulatory relationships between TFs and target genes, and biological processes and signaling pathways of TFs in cancers. TFcancer not only provides a user-friendly interface for browsing and searching but also allows flexible data downloading and user data submitting. It is believed that TFcancer is a helpful and valuable resource for researchers who seek to understand the functions and molecular mechanisms of TFs involved in human cancers.
Availability And Implementation:
The TFcancer are freely available at http://lcbb.swjtu.edu.cn/tfcancer/.
Supplementary Information:
Supplementary data are available at Bioinformatics online.
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