Cycloaddition of cyclopropanes for the elaboration of medium-sized carbocycles
Julien Caillé1, Raphaël Robiette2
1Institute of Condensed Matter and Nanosciences, Université catholique de Louvain, Place Louis Pasteur 1 box L4.01.02, 1348 Louvain-la-Neuve, Belgium. raphael.robiette@uclouvain.be and Institut de Chimie et des Matériaux Paris Est (ICMPE), UMR-CNRS 7182, Université Paris Est Créteil (UPEC), 2 Rue Henri Dunant, 94320 Thiais, France. julien.caille@icmpe.cnrs.fr.
Abstract:
The stereocontrolled formation of medium-sized carbocycles is a major goal in modern organic chemistry due to their widespread occurrence in natural products and pharmaceutically active ingredients. One approach consists in the use of cycloaddition reactions which notably results in high selectivities and atom-economy. To this end, cyclopropanes are ideal substrates since they can provide readily functionalized three- or five-carbon synthons. Herein we report advances made in cycloaddition reactions of cyclopropanes towards the synthesis of medium-sized carbocycles via transition metal catalysis or Lewis acid catalysis.
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