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Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
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Relationship between autoimmune thyroid disease and nephropathy: A clinicopathological study
Liping Zhao1, Yunxiao Liu, Hongchang Su
1Department of Pathology, Shanxi Provincial People's Hospital, Taiyuan City, Shanxi Province, China.
Medicine
|June 11, 2021
Summary
Thyroid autoantibodies, including thyroglobulin antibody (TG-Ab) and thyroid peroxidase antibody (TPO-Ab), are more prevalent in the kidneys of patients with autoimmune thyroid disease (AITD) and nephropathy, suggesting a role in kidney disease development.
Area of Science:
- Nephrology
- Immunology
- Endocrinology
Background:
- The association between autoimmune thyroid disease (AITD) and nephropathy is recognized, but the specific role of thyroid autoantibodies in kidney disease remains unclear.
- Limited data exists on the direct relationship between circulating and kidney-expressed thyroid autoantibodies and the pathological types of nephropathy.
Purpose of the Study:
- To investigate the association between thyroid autoantibodies and nephropathy in patients with concurrent AITD.
- To analyze the prevalence of thyroglobulin antibody (TG-Ab) and thyroid peroxidase antibody (TPO-Ab) in kidney tissue of nephropathy patients with and without AITD.
- To explore the relationship between specific nephropathy types and thyroid autoantibody levels.
Main Methods:
- Retrospective study of 246 nephropathy patients, including 82 with AITD.
- Analysis of general characteristics, thyroid function, autoantibodies, and nephropathy pathology.
- Immunohistochemistry to detect TG-Ab and TPO-Ab in kidney tissue.
Main Results:
- Nephropathy patients with AITD showed higher serum levels of TPO-Ab, TG-Ab, TR-Ab, and IgG.
- The AITD group had higher proportions of membranous nephropathy (MN) and focal segmental glomerulosclerosis (FSGS).
- Kidney TPO-Ab and TG-Ab were more prevalent in nephropathy patients with AITD.
Conclusions:
- Thyroid peroxidase antibody (TPO-Ab) and thyroglobulin antibody (TG-Ab) expression is more common in the kidneys of patients with nephropathy and AITD.
- These autoantibodies may contribute to the pathogenesis of AITD-related nephropathy.
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