Related Experiment Video
Updated: Nov 2, 2025

Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods
Published on: August 4, 2022
Stigma Surrounding the Use of Medically Assisted Treatment for Opioid Use Disorder
Tricia H Witte1, Jessica Jaiswal1, Mercy N Mumba1
1The University of Alabama, Tuscaloosa, AL, USA.
Purpose:
This study sought to determine whether certain factors influenced public stigma toward the use of medication to treat opioid use disorders (MOUD). Method: In a series of 3 studies using between-subjects designs, hypothetical MOUD patients matched in age and educational status with the participants were varied in systematic ways to determine whether certain factors influenced stigmatizing views of the patients. Results: Study 1 (n = 142) determined that stigma levels were elevated for hypothetical patients receiving agonist medication for OUD compared to other medications or no medication at all. Study 2 (n = 144) found that hypothetical patients receiving opioid agonist medication for either heroin or pain pills were equally stigmatized and stigmatized more than hypothetical patients on nicotine agonist medication. Study 3 (n = 151) showed that stigmatizing attitudes did not change as a result of enhanced treatment services for hypothetical MOUD patients (i.e. therapy as a supplement to medication). Conclusions/Importance: Results indicate that patients receiving agonist medication for an OUD may be the target of public stigma. Public education on the efficacy of agonist medications for OUD is urgently needed to help reduce such stigma, which may facilitate treatment delivery, treatment adherence, and treatment success.
Insights
Public stigma is higher for patients receiving agonist medication for opioid use disorder (OUD). Public education on medication efficacy is needed to reduce stigma and improve treatment outcomes for OUD.
Area of Science:
- Addiction medicine
- Public health
- Psychiatry
Background:
- Opioid use disorder (OUD) is a significant public health concern.
- Medications for opioid use disorder (MOUD) are effective treatments.
- Public stigma can be a barrier to treatment access and adherence.
Purpose of the Study:
- To investigate factors influencing public stigma toward medication for opioid use disorder (MOUD).
- To identify specific medications or treatment characteristics associated with higher stigma.
Main Methods:
- Three studies with between-subjects designs were conducted.
- Hypothetical MOUD patients were systematically varied to assess participant views.
- Stigma levels were measured in response to different medication types and treatment enhancements.
Main Results:
- Agonist medications for OUD elicited higher stigma compared to other medications or no medication.
- Stigma was similar for patients receiving agonist medication for heroin or pain pills.
- Enhanced treatment services, such as supplemental therapy, did not reduce stigma.
Conclusions:
- Patients receiving agonist medications for OUD face significant public stigma.
- Public education on the effectiveness of agonist medications is crucial.
- Reducing stigma can improve treatment delivery, adherence, and success for OUD.
More Related Videos
Related Concept Videos
Analgesia and Pain Management
Drug Abuse and Addiction: Pharmacological Phenomena
Substance Use Disorders Affecting Sleep
Understanding the concepts of physical dependence,...
Opioid Analgesics: Synthetic and Semisynthetic Opioids
Drug Dependence
Opioid Analgesics: Morphine and Other Natural Cogeners

