Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Development of the Lymphatic System01:15

Development of the Lymphatic System

1.4K
The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
1.4K
Lymphatic Vessels and Lymph Transport01:16

Lymphatic Vessels and Lymph Transport

20.0K
Lymphatic vessels, known as lymphatics, are crucial in transporting lymph from peripheral tissues to our venous system. This process begins with lymph entering through tiny capillaries that branch through tissues. These capillaries have unique features such as larger diameters, thinner walls, and a distinctive one-way valve system formed by overlapping endothelial cells.
This one-way system allows fluids, solutes, and even pathogens to enter but prevents their return to the intercellular...
20.0K
Functions of the Lymphatic and Immune System01:28

Functions of the Lymphatic and Immune System

5.1K
The lymphatic system plays a crucial role in bolstering our immune system. It consists of a network of lymphoid organs, lymph, and lymphatic vessels that provide structural and functional support in safeguarding the body against pathogens such as viruses and bacteria.
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
5.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Engineering Bioactive Liposomal Nanoparticles for Kidney-Targeted ECFC Backpacks.

ACS applied bio materials·2026
Same author

Harnessing NCX-IP <sub>3</sub> R-dependent Calcium Oscillations to Regulate Angiogenic Signaling in Endothelial Cells.

bioRxiv : the preprint server for biology·2026
Same author

Hypoxia-induced drug-resistance bias 3D cancer spheroid drug screens.

APL bioengineering·2026
Same author

Blocking glutamine transport normalizes lymphatic vessels in hypoxic environments by attenuating glycolysis.

bioRxiv : the preprint server for biology·2026
Same author

Metabolically Driven Differentiation of Human Pluripotent Stem Cells to Generate Robust and Functional Lymphatic Endothelial Cells.

bioRxiv : the preprint server for biology·2025
Same author

Intracellular pH dynamics respond to extracellular matrix stiffening and mediate vasculogenic mimicry through β-catenin.

Cell death & disease·2025
Same journal

Injectable pH-responsive gelatin methacryloyl hydrogel for cuproptosis-syn ergized sunitinib therapy and immune reprogramming in clear cell renal cell carcinoma.

Acta biomaterialia·2026
Same journal

Corrigendum to "Injectable hydrogel-assisted local lipopolysaccharide delivery improves immune checkpoint blockade therapy" [Acta Biomaterialia 2025, 194, 153-168].

Acta biomaterialia·2026
Same journal

Enhanced Antithrombogenic Performance of Microfluidic Oxygenators through Dual Bioactive Surface Modification for an Artificial Placenta System.

Acta biomaterialia·2026
Same journal

Interface engineering to enhance properties of bioprosthetic heart valve materials with polysaccharide nanocomposite-conjugated hydrogels.

Acta biomaterialia·2026
Same journal

Thermoresponsive hydrogel for long-acting delivery of structurally intact and biologically active Fab fragment and monoclonal antibody.

Acta biomaterialia·2026
Same journal

Cell crowding initiates tumor invasion by triggering a nanoscale topography transition of plasma membranes.

Acta biomaterialia·2026
See all related articles

Related Experiment Video

Updated: Nov 2, 2025

Intra-lymph Node Injection of Biodegradable Polymer Particles
09:06

Intra-lymph Node Injection of Biodegradable Polymer Particles

Published on: January 2, 2014

14.8K

Harnessing biomaterials for lymphatic system modulation.

Laura Alderfer1, Eva Hall1, Donny Hanjaya-Putra2

  • 1Bioengineering Graduate Program, University of Notre Dame, Notre Dame, IN 46556, USA; Aerospace and Mechanical Engineering, University of Notre Dame, Notre Dame, IN 46556, USA.

Acta Biomaterialia
|June 12, 2021
PubMed
Summary
This summary is machine-generated.

Biomaterials offer new ways to study the lymphatic system, improving our understanding of diseases like cancer and inflammation. This knowledge can lead to better drug delivery and tissue regeneration strategies.

Keywords:
BiomaterialsDrug deliveryImmune systemLymphatic vesselsTissue engineering

More Related Videos

Blocking Lymph Flow by Suturing Afferent Lymphatic Vessels in Mice
05:59

Blocking Lymph Flow by Suturing Afferent Lymphatic Vessels in Mice

Published on: May 14, 2020

6.7K
Author Spotlight: Developing Photo-Stimulation Technology for Toxin Removal in Sleep-Related Brain Diseases
07:56

Author Spotlight: Developing Photo-Stimulation Technology for Toxin Removal in Sleep-Related Brain Diseases

Published on: June 28, 2024

1.0K

Related Experiment Videos

Last Updated: Nov 2, 2025

Intra-lymph Node Injection of Biodegradable Polymer Particles
09:06

Intra-lymph Node Injection of Biodegradable Polymer Particles

Published on: January 2, 2014

14.8K
Blocking Lymph Flow by Suturing Afferent Lymphatic Vessels in Mice
05:59

Blocking Lymph Flow by Suturing Afferent Lymphatic Vessels in Mice

Published on: May 14, 2020

6.7K
Author Spotlight: Developing Photo-Stimulation Technology for Toxin Removal in Sleep-Related Brain Diseases
07:56

Author Spotlight: Developing Photo-Stimulation Technology for Toxin Removal in Sleep-Related Brain Diseases

Published on: June 28, 2024

1.0K

Area of Science:

  • Biomaterials Science
  • Immunology
  • Vascular Biology

Background:

  • The lymphatic system's role in immune cell trafficking and macromolecule transport is crucial but less understood than the vascular system.
  • Understanding the lymphatic system is key to addressing diseases like cancer metastasis and inflammation.
  • Biomaterials provide a powerful tool to investigate lymphatic functions and disease mechanisms.

Purpose of the Study:

  • To review recent advances in biomaterials for lymphatic system research.
  • To explore how biomaterials can enhance understanding of lymphatic-immune interactions.
  • To discuss the application of biomaterials in drug delivery and immunomodulation via the lymphatic system.

Main Methods:

  • Review of current literature on biomaterials and the lymphatic system.
  • Analysis of biomaterial applications in lymphatic vessel formation and drug delivery.
  • Examination of models for studying lymphatic-immune cell interactions.

Main Results:

  • Biomaterials are advancing the study of lymphatic vessel formation and function.
  • Novel models are improving our understanding of lymphatic-immune cell interactions.
  • Biomaterials show promise for targeted drug delivery and immunomodulation through the lymphatic system.

Conclusions:

  • Biomaterials are essential for elucidating the lymphatic system's role in health and disease.
  • Further research into biomaterials can lead to improved therapeutic strategies.
  • Addressing challenges in biomaterial application is crucial for future advancements in lymphatic research and treatment.