Hyaluronic acid based microneedle array: Recent applications in drug delivery and cosmetology

Microneedles are micron-sized arrays of needles that facilitate drug delivery for local and systemic effects. Hyaluronic acid (HA) is a glycosaminoglycan and is an indigenous component of the connective tissues and dermis. Owing to its versatility and biocompatibility, it has widely been used against various bone, eye, and skin disorders. Therefore, fabricating HA-microneedles is fetching massive global attention. HA based dissolvable microneedles have been immensely explored due to their biodegradable nature. Its degradation residues are very safe. Several attempts have been made to deliver vitamins, proteins, DNAs, and biological macromolecules by HA-microneedles. Here we present the recent advancements in HA-microneedles based application on drug delivery and cosmetology. Its bio-degradation pathways, the receptors on which HA and its derivatives interact, the biological half-lives, and their importance as useful materials for various applications are highlighted. The literature reports identify HA-microneedle as an useful carrier for the delivery of pharmaceuticals.