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Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

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Hyperthyroidism Prevalence in China After Universal Salt Iodization.

Chuyuan Wang¹, Yongze Li¹, Di Teng¹

¹Department of Endocrinology and Metabolism, The First Affiliated Hospital of China Medical University, Shenyang, China.

Frontiers in Endocrinology

|June 14, 2021

Summary

This summary is machine-generated.

Universal salt iodization in China has maintained stable hyperthyroidism rates. Key risk factors include iodine imbalance, thyroid antibodies, and middle age, with severe subclinical hyperthyroidism mirroring overt hyperthyroidism.

Keywords:

Graves’ disease cross-sectional study hyperthyroidism iodine intake thyroid autoimmune antibodies

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Area of Science:

Endocrinology
Public Health
Epidemiology

Background:

Universal salt iodization (USI) was implemented in China in 1996.
The long-term impact of USI on hyperthyroidism prevalence and risk factors requires evaluation.

Purpose of the Study:

To examine the prevalence of hyperthyroidism and its associated risk factors in mainland China after two decades of USI.

Main Methods:

Utilized data from the TIDE 2015-2017 survey, encompassing 78,470 participants from 31 provinces.
Measured iodine status, thyroid hormones, and thyroid antibodies to assess hyperthyroidism and related factors.

Main Results:

Prevalence of overt hyperthyroidism (OH) was 0.78% and Graves' disease (GD) was 0.53%.
Both excessive and deficient iodine intake were linked to increased OH risk; iodine deficiency was associated with GD.
Elevated thyroid antibodies correlated significantly with OH and GD, but not subclinical hyperthyroidism.

Conclusions:

Hyperthyroidism prevalence remains stable in China post-USI.
Iodine deficiency, elevated thyroid antibodies, and middle age are primary risk factors for OH and GD.
Severe subclinical hyperthyroidism shares risk factors with overt hyperthyroidism.