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Updated: Nov 2, 2025

An Additive Manufacturing Technique for the Facile and Rapid Fabrication of Hydrogel-based Micromachines with Magnetically Responsive Components

An Additive Manufacturing Technique for the Facile and Rapid Fabrication of Hydrogel-based Micromachines with Magnetically Responsive Components

Published on: July 18, 2018

Hydrogel microparticles for biomedical applications.

Andrew C Daly^1,2, Lindsay Riley^3,2, Tatiana Segura^3,4

¹Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.

Nature Reviews. Materials

|June 14, 2021

Summary

This summary is machine-generated.

Hydrogel microparticles (HMPs) offer versatile biomedical solutions for cell and drug delivery and tissue engineering. These microparticles provide tunable properties for advanced therapeutic and biofabrication applications.

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Area of Science:

Biomaterials Science
Tissue Engineering
Drug Delivery

Background:

Hydrogel microparticles (HMPs) are versatile platforms for biomedical applications.
They enable the encapsulation of biologics like cells and drugs.
HMPs offer advantages over traditional bulk hydrogels in various therapeutic strategies.

Purpose of the Study:

To review fabrication techniques for hydrogel microparticles.
To discuss the multiscale behaviors and functional properties of HMP systems.
To highlight the applications of HMPs in cell delivery, drug delivery, scaffold design, and biofabrication.

Main Methods:

Review of existing literature on HMP fabrication and applications.
Discussion of techniques including batch emulsion, microfluidics, lithography, electrohydrodynamic (EHD) spraying, and mechanical fragmentation.
Analysis of HMP formulation in suspensions, granular hydrogels, and embedded systems.

Main Results:

HMPs can be fabricated with controlled shapes and sizes for specific biomedical needs.
Formulations include injectable suspensions and granular hydrogels for minimally invasive delivery.
HMPs exhibit modular properties, especially when mixed, offering tunable functionalities.

Conclusions:

Hydrogel microparticles represent a significant advancement in therapeutic delivery and tissue engineering scaffolds.
Their tunable properties and fabrication methods allow for tailored solutions in regenerative medicine and biofabrication.
HMPs provide a promising alternative to conventional bulk hydrogels, enhancing therapeutic efficacy and material design.