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Doxycycline Therapy for Abdominal Aortic Aneurysm: Inhibitory Effect on Matrix Metalloproteinases

Smit Paghdar1,2, Taheseen M Khan1, Nishant P Patel3,4

  • 1Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.

Cureus
|June 14, 2021
PubMed

Insights

Doxycycline may prevent the growth of small abdominal aortic aneurysms (AAAs) by inhibiting matrix metalloproteinases (MMPs). This could reduce the need for invasive surgery and prevent life-threatening ruptures.

Area of Science:

  • Vascular Biology
  • Pharmacology

Background:

  • Abdominal aortic aneurysm (AAA) is a serious condition linked to smoking, aging, and atherosclerosis.
  • Matrix metalloproteinases (MMPs) play a role in AAA development through tissue degradation.
  • Current AAA treatment is primarily surgical repair.

Purpose of the Study:

  • To investigate the relationship between doxycycline and MMPs.
  • To determine if doxycycline can prevent the growth of small abdominal aortic aneurysms (AAAs).

Main Methods:

  • Literature review using PubMed, Google Scholar, The Journal of Vascular Surgery, and ResearchGate.
  • Analysis of studies on doxycycline's effect on MMPs and AAA growth.

Main Results:

  • Doxycycline demonstrates an inhibitory effect on MMPs.
  • Evidence supports doxycycline's potential in preventing the expansion of small AAAs.

Conclusions:

  • Therapeutic use of doxycycline may halt AAA progression.
  • Doxycycline treatment could avert aneurysm rupture and decrease reliance on costly surgical interventions.
Keywords:
abdominalaortic aneurysmdoxycyclinematrix metalloproteinase

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