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A Giant Left Intraventricular Thrombus Associated With Apical Hypertrophic Cardiomyopathy Mimics Cancer

Nadia Raza1, Shane Burnette2, Fowrooz S Joolhar3

  • 1Internal Medicine, University of California, Los Angeles (UCLA) Kern Medical Center, Bakersfield, USA.

Cureus
|June 14, 2021
PubMed

Insights

Apical hypertrophic cardiomyopathy (AHCM) can rarely lead to left ventricular thrombus (LVT), complicating diagnosis with symptoms mimicking malignancy. This case highlights the importance of considering LVT in AHCM patients presenting with atypical symptoms.

Area of Science:

  • Cardiology
  • Oncology

Background:

  • Hypertrophic cardiomyopathy (HCM) is a myocardial disease often inherited, with apical hypertrophic cardiomyopathy (AHCM) being a rare variant.
  • Atrial thrombus is a known complication of HCM, particularly with atrial fibrillation (AF).

Observation:

  • A 57-year-old female with AHCM presented with unexplained anemia and significant weight loss.
  • Imaging revealed a large left intraventricular mass, raising suspicion for either a tumor or ventricular thrombus.

Findings:

  • The case presented a diagnostic challenge due to the mass size and symptoms suggestive of malignancy.
  • Left ventricular thrombus (LVT) is an uncommon complication of HCM, making this case particularly noteworthy.

Implications:

  • This case underscores the need to consider LVT in the differential diagnosis of intraventricular masses in AHCM patients.
  • It highlights the diagnostic complexities when symptoms overlap between thromboembolic events and malignancy in cardiovascular disease.

Keywords:
apical hypertrophy cardiomyopathygiant lv thrombushypertrophy cardiomyopathyleft ventricle (lv) thrombuslv thrombus

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