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Related Experiment Video

Updated: Nov 2, 2025

Fabrication of Three-dimensional Paper-based Microfluidic Devices for Immunoassays
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Microfluidic Paper-Based Analytical Devices: From Design to Applications.

Eka Noviana1, Tugba Ozer2,3, Cody S Carrell2

  • 1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, Indonesia 55281.

Chemical Reviews
|June 14, 2021
PubMed
Summary

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This summary is machine-generated.

Microfluidic paper-based analytical devices (μPADs) offer a low-cost, equipment-free platform for various applications. This review details their fabrication, design, detection, and applications, outlining future directions for this promising technology.

Area of Science:

  • Analytical Chemistry
  • Materials Science
  • Biotechnology

Background:

  • Microfluidic paper-based analytical devices (μPADs) have emerged as a significant analytical platform.
  • μPADs offer advantages over traditional microfluidics, including low cost and ease of fabrication.
  • They enable flow manipulation without external equipment and allow for reagent storage.

Purpose of the Study:

  • To provide a comprehensive review of microfluidic paper-based analytical devices (μPADs).
  • To highlight fabrication methods, device designs, detection strategies, and applications of μPADs.
  • To discuss the future potential and necessary advancements in the field.

Main Methods:

  • Review of existing literature on microfluidic paper-based analytical devices.

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  • Analysis of various fabrication techniques, including patterning methods.
  • Examination of different device designs and modifications for diverse assay requirements.
  • Compilation of various detection strategies employed in μPADs.
  • Survey of current and emerging applications of μPADs.

    • Main Results:

    • Established fabrication methods offer distinct advantages and disadvantages.
    • Device designs can be modified to suit specific assay needs.
    • A range of detection strategies are available for μPADs.
    • μPADs have demonstrated growing applicability across various fields.

    Conclusions:

    • μPADs represent a versatile and cost-effective analytical platform.
    • Continued research and development are crucial for realizing the full potential of μPADs.
    • Standardization of fabrication and integration of advanced detection methods will drive future innovation.