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The prognostic relevance of 14-3-3ξ expression in cancers: A meta-analysis
Caihong Li1, Changlu Liu1, Ya Liu1
1Department of Respiratory, The Third Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.
Objective:
To gain an enhanced understanding of the prognostic importance of 14-3-3ξ levels in cancer patients.
Methods:
The meta-analysis and systematic review was conducted in October 2019. Two reviewers independently reviewed Web of Science, Embase and PubMed databases to identify published studies using relevant key words. The correlation between the level of 14-3-3ξ and cancer patient survival was assessed based upon pooled hazard ratios and 95% confidence intervals derived from the selected studies. Data was analysed using STATA 12.
Results:
Of the 244 studies initially identified, 22(9%) were included, and they comprised 2,676 patients. Elevated 14-3-3ξ level correlated significantly with poorer overall survival (hazard ratio: 1.93; 95% confidence interval: 1.42-2.61) in cancer patients. With respect to disease-free survival, the pooled hazard ratio for cancer patients expressing high levels of 14-3-3ξ was 1.89 (95% confidence interval: 1.56-2.30). Patients with elevated 14-3-3ξ expression also exhibited reduced cancer-specific survival (hazard ratio: 3.47; 95% confidence interval: 2.12-5.69).
Conclusions:
Higher level of 14-3-3ξ correlated with poorer patient prognosis in a range of cancer types.
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